Abstract: 【Abstract】Objective To observe the curative effect of peritoneal dialysis combined with hemodialysis in the treatment of chronic renal failure associated with refractory hypertension. Method Sixteen patients were enrolled in this study. 24-hour ambulatory blood pressure monitoring, echocardiography, brain natriuretic
peptide (BNP), and solute clearance rates were compared before the combination therapy and after the therapy for 6 months. Results After the combination therapy for 6 months, average number of antihypertensive drugs reduced from 4.2 to 2.8; average systolic pressure in 24 hours (t=15.602, P =0.000), average diastolic pressure in 24 hours (t =12.358, P =0.000), average systolic pressure in daytime (t =19.457, P =0.000), average diastolic pressure in daytime (t =49.694, P =0.000), average systolic pressure in night time (t =31.379, P = 0.000), and average diastolic pressure in night time (t =17.777, P =0.000) were lower than those before the combined therapy; BNP (t=-2.172, P=0.030) and mass index of left ventricle (t=10.429, P=0.000) were also lower than those before the therapy; total Kt/V was higher (t=-16.801, P=0.000) than that before the therapy. Conclusion Peritoneal dialysis combined with hemodialysis can increase dialysis adequacy, reduce blood pressure, and improve left ventricle hypertrophy.

Key words: Chronic Renal Failure, Peritoneal Dialysis and Hemodialysis Combination Therapy, Resistant Hypertension