Abstract: 【Abstract】Objective To study the association between serum iPTH and left ventricular hypertrophy (LVH) and to explore the incidence and related factors of LVH in peritoneal dialysis (PD) patients in a single dialysis center. Methods Clinical data of the 122 PD patients admitted to Shenzheng Second People’s Hospital during the period from Jan. 2006 to Aug. 2013 were recruited and retrospectively analyzed. Subjects were divided into three groups, group A (iPTH＜150 pg/ml, n=36), group B (iPTH 150～300 pg/ml, n=36), and group C (iPTH＞300 pg/ml, n=50). Correlation analysis was conducted between serum iPTH and the echocardiographic indicators of EF, IVST, and LVMI. Regression analysis was used to determine the relationship between LVH and the parameters of gender, age, hypertension, diabetes, serum iPTH, CRP, uric acid, BNP and homocysteine, Kt/V, and PD duration. Results LVH was found in 74 (60.7%) cases including 41 males (55.4%) and 33 females (44.6%). In the 74 LVH patients, 38 patients (51.4%) were >60 years old and 36 patients (48.6%) were <60 years old. The average age was 56.20±14.57 years old in LVH patients and was 54.17±15.21 years old in patients without LVH (t = 2.452; P = 0.230). Serum iPTH correlated negatively with EF (P = 0.004) and positively with IVST (P = 0.001) and LVMI (P = 0.020). Multivariate logistic regression analysis showed that hypertension (P=0.013), diabetes (P=0.015), and iPTH (P=0.035) were the independent risk factors for LVH in PD patients. Conclusion The incidence of LVH in this series of PD patients was 60.7%. Higher serum iPTH contributed to cardiovascular complications in PD patients.

Key words: Peritoneal dialysis, Parathyroid hormone, Left ventricular hypertrophy