Abstract: Object To investigate the effect of life style and nutrition on bone metabolism in maintenance hemodialysis (MHD) patients from central city and countryside of Beijing. Method Eighty- eight MHD patients living in Beijing area were divided according to their living places into two groups, central city group (n=48) and countryside group (n=40). Serum iPTH, Ca, P, albumin (ALB), total protein (TP), total ironbinding capacity (TIBC), cretinine (Scr), BUN, total cholesterol (TC), and Hb, lymphocyte count (LC), Kt/V, and bone mineral density (BMD) were measured. Result The overall up- and to- standard rates of Ca (60.00% vs. 39.58%, χ2=3.640, P=0.045), P (55.00% vs. 33.33%, χ2=4.175, P=0.034) and iPTH (42.50% vs. 22.92%, χ2=3.857, P=0.041) were better in countryside group than in central city group. The average daily physical activity time was longer in countryside group than in central city group (P<0.05). The morbidity of osteoporosis (15.00% vs. 37.50%, χ2=9.697, P=0.002) and osteopenia (55.00% vs. 54.16%, χ2=4.099, P= 0.040) were lower in countryside group than in central city group (P<0.05). There was a positive correlation between bone density and average daily physical activity time (r=0.502, P=0.000). No significant differences
in Kt/V and malnutrition-inflammation score were found between the two groups. Conclusion Appropriate diet and physical activity are essential to maintain a normal bone metabolism in MHD patients.

Key words: Hemodialysis, Bonemetabolism, Bone density, Nutrition status