Abstract: Objective To research the influence of regularly urokinase and heparin sealed tube to the long-term hemodialysis catheter tube in prevention of infection, so as to find out the clinical significance of regular application of urokinase and heparin seal tube. Methods We selected 60 patients using right internal jugular vein long-term indwelling catheter with cuff as vascular access line maintenance hemodialysis during April 2014-March 2015 in our hospital dialysis centers, and randomly divided them into two groups (the experimental group and control group, each group of 30 patients). The experimental group with a catheter-locking
regimen of urokinase and heparin once weekly ,with heparin used in the other sessions.; The control group only with a catheter-locking regimen of heparin. Results The experimental group can obviously reduce the incidence rate of catheter infection (3.3% vs. 25%；χ2=4.043，P=0.044); In the experimental group before and after treatment ,there were no significant changes in PT[(13.93±1.82)s vs. 13.89±1.92)s，t=3.129，P=0.894]、PLT[(190.59±49.65)×109/L vs. (193.91±39.68)×109/L，t=0.393，P=0.617]、INR [(1.2±0.20 )s vs. (1.21± 0.15)s，t=0.619，P=0.751]、APTT [(33.85±6.51)s vs. (33.99±7.12)s，t=0.297，P=0.814]、FIB [(2.98±0.78)g/L vs. (3.06±0.76)g/L，t=0.706，P=0.483]and TT [(11.37±1.59)s vs. (11.91±1.54)s，t=0.587，P=0.523]. Conclusion Regularly urokinase and heparin sealed tube to the long-term hemodialysis catheter tube can reduced the incidence of infection , It is safe and effective to prevention of catheter-related bacteremia.

Key words: Hemodialysis, Urokinase, Catheter tube