Abstract: Severely burned patients remain to have high mortality and serious prognosis, and are in need of efforts to improve their treatment. Strong systemic response to burn injury manifested as stress status, hypercytokinemia and hypermetabolism plays an important role in the deterioration to severe clinical condition and unfavorable outcome in these patients. Acute kidney injury (AKI) in burned patients has some characteristics such as apparent glomerular and tubular damages, of which the malfunctional status and damage severity may not be exactly reflected by conventional parameters such as the increase of serum creatinine. Rhabdomyolysis and associated AKI may also be common in these patients. Despite the lack of clinical experience on evidence- based medicine about continuous renal replacement of therapy (CRRT) for severely burned patients, CRRT may stabilize clinical conditions and obtain a better outcome by alleviating stress reactions and hypermetabolism, continuously removing toxins from circulation, and maintaining homeostasis from the point of view of pathological changes and clinical course in burn injury. However, several practical issues about CRRT including catheter-related infection, anticoagulation and drug dose adjustment need to be studied further.

Key words: Severe burn, Acute kidney injury, Systemic inflammation response syndrome, Continuous renal replacement therapy