Abstract: Objective To investigate the correlation of nutritional and inflammatory state with coronary arteriosclerosis disease (CAD) in maintenance hemodialysis (MHD) patients. Methods MHD patients treated in Beijing Tongren Hospital for more than 3 months with stable conditions were enrolled in this study. They were divided into CAD group and non-CAD group according to the presence or absence of CAD. General conditions, blood routine and serum biochemical indexes were compared between the two groups using SPSS18.0 software. Results A total of 68 patients (36 males and 32 females; average age 61.3±14.0 years) were recruited, including 19 patents in CAD group (27.94%) and 49 patients in non-CAD group (72.06%). Age (72.21±7.64 vs. 57.04±13.69, t=4.549, P＜0.001), diabetes (63.16% vs. 26.53%, χ2=7.901, P=0.010), serum albumin (33.42±4.22 vs. 36.19±3.38, t=-2.825, P=0.007), serum creatinine (754.05±216.86 vs. 963.06± 240.15, t=-3.305, P=0.002), high sensitive C-reactive protein (11.26±17.05 vs. 4.29±5.23, t=2.588, P=0.013) and neutrophil/lymphocyte ratio (3.65±1.61 vs. 2.72±0.90, t=3.027, P=0.002) differed significantly between the two groups. While gender, serume triglyceride, total cholesterol, low density lipoprotein cholesterol (LDLC) and high density lipoprotein cholesterol (HDL-C) had no differences between the two groups (P＜0.05). Logistic regression indicated that age (OR=1.150, 95% CI 1.042~1.257, P=0.010) and diabetes (OR=9.721, 95% CI 8.006~11.436, P=0.009) independently correlated with CAD in MHD patients. Conclusion In MHD patients, nutritional and inflammatory indices differed significantly in patients with CAD and those without CAD. However, they were not the independent risk factor for CAD, while age and diabetes independently correlated with CAD.

Key words: hemodialysis, coronary arteriosclerosis disease,, malnutrition, inflammationmalnutrition, inflammation