Abstract: Objective To investigate the relationship between serum ferritin and compliance rate of hemoglobin (HGB) level in maintenance hemodialysis (MHD) patients. Methods Clinical data of MHD patients treated in this center between Jan. 2012 to Dec. 2016 were recruited. We defined serum ferritin 13-500μg/L as normal level and that >500μg/L as high serum ferritin. MHD patients were divided into normal ferritin group and high ferritin group. The target HGB level is 110～130g/L. Demographic characteristics, HGB level and HGB compliance rate were compared between the two groups. Results A total of 110 MHD patients were enrolled in this study. (a) Dialysis age was longer in high ferritin group than in normal ferritin group(120.960 ± 68.148 vs. 73.920 ± 61.104, t=3.780, P<0.001), while patients’age was younger in high ferritin group than in normal ferrtin group (54.300±13.421 years vs. 62.180 ± 12.110 years, t=3.204, P =0.002). (b) There were no significant differences in HGB level (110.300 ± 14.575g/L in high ferritin group, 107.060 ±18.323g/L in normal ferritin group, t=1.033, P=0.304), and HGB compliance rate (76.667% in high ferritin group and 70.000% in normal ferritin group, c2=0.624, P=0.429) between the two groups. Conclusion Serum ferritin more than 500μg/L could not improve HGB level and its compliance rate. Clinically, rational use of iron supplement for anemia not leading to high serum ferritin should be emphasized.

Key words: Renal dialysis, Ferritin, Hemoglobin, Compliance rate, Transferrin saturation