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Chinese Journal of Blood Purification ›› 2017, Vol. 16 ›› Issue (02): 121-125.doi: 10.3969/j.issn.1671-4091.2017.02.013
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Abstract: Objective To investigate the hemoglobin level and its related factors in patients on peritoneal dialysis (PD). Methods All patients initiated PD in the period from Jan. 2000 to May 2013 in Renji Hospital, Shanghai Jiao Tong University School of Medicine and continued on PD for ≥3 months with complete data were enrolled in this study. Patients were followed up for at least 36 months or until death, transferred to hemodialysis or other centers, or lost of our follow-up. Percentage of patients with hemoglobin 100-120g/L was calculated at predialysis, PD for 1, 6, 12, 24 and 36 months. Multivariate regression analysis was used to determine the related factors for hemoglobin level. Results A total of 521 patients were enrolled in this study. Among them, 256 (49.1%) were males, the mean age was 54.3±14.8 years, and 110 (21.1%) patients had diabetes mellitus. Before PD, the percentage of patients with hemoglobin 100~120g/L was 14.8%, and the percentage increased to 36.3%, 40.7%, 43.8%, 42.1% and 42.6% on PD for 1, 6, 12, 24 and 36 months respectively (P<0.001). The percentage of patients having targeted hemoglobin level (100~120g/L) was significantly higher after PD as compared with that of before PD (χ2=207.112, P<0.001 after one month; χ2=230.008, P<0.001 after 6 months; χ2=189.613, P<0.001 after 12 months; χ2=162.607, P<0.001 after 24 months; χ2=168.074, P<0.001 after 36 months). Multivariate regression analysis showed that phosphorus (β =-0.104, P= 0.023), serum albumin (β=0.167, P<0.001), fasting blood glucose (β= 0.110, P=0.016), transferrin saturation (β=0.482, P<0.001) and residual renal function (β=0.127, P=0.006) were the independent factors relating to hemoglobin level on PD for one month, and that transferrin saturation (β=0.494, P<0.001) and residual renal function (β =0.482, P<0.001) were the independently factors relating to hemoglobin level on PD for 36 months. Conclusions PD can significantly cause the increase of hemoglobin level, but the percentage of patients having targeted hemoglobin level (100~120g/L) was unsatisfactory. Transferrin saturation and residual renal function were the independent factors affecting the hemoglobin level in PD patients.
Key words: Peritoneal dialysis, Hemoglobin, Transferrin saturation, Residual renal function
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URL: https://www.cjbp.org.cn/EN/10.3969/j.issn.1671-4091.2017.02.013
https://www.cjbp.org.cn/EN/Y2017/V16/I02/121