Abstract: Objective To analyze the risk factors and prevalence of pulmonary hypertension (PH) in peritoneal dialysis (PD) patients. Methods Clinical, laboratory and echocardiographic data from 109 PD patients were retrospectively analyzed. The risk factors for PH were investigated by comparison between groups. Logistic regression was used for the analyses. Results Fifty of the 109 patents (45.87%) had PH. Compared to the patients without PH, patients with PH had lower levels of plasma albumin (ALB) (t=4.424, P＜0.001), hemoglobin (Hb) (t=3.318, P=0.001) and left ventricular ejection fraction (LVEF) (t=2.287, P= 0.024), and higher levels of calcium-phosphorus product (t=-2.198, P=0.030), left atrial diameter (LA) (t=-3.961, P＜0.001), main pulmonary artery (MPA) (t=-2.878, P=0.005), left ventricular end-systolic diameter (LVDs) (t=-3.438, P=0.001), left ventricular end-diastolic diameter (LVDd) (t=-2.662, P=0.009) and interventricular septal thickness (IVST) (t=-2.953, P=0.004). Univariate regression analyses showed that pulmonary artery systolic pressure (PASP) was negatively correlated with ALB (β=-0.206, P＜0.001), Hb (β=-0.033, P=0.002) and LVEF (β =-0.050, P=0.027), and was positively correlated with calcium-phosphorus product (β = 0.421, P=0.035), LA (β=0.138, P=0.001), LVDd (β=0.084, P=0.013) and LVDs (β=0.114, P=0.003). Multivariate regression analyses displayed that ALB (OR 0.786, 95% CI 0.690～0.896, P＜0.001), LA (OR 1.117, 95% CI 1.019～1.224, P=0.018) and calcium- phosphorus product (OR 2.509, 95% CI 1.312～4.799, P=0.005) were the independent risk factors for PASP. Conclusions PH was relatively prevalent in PD patients. The decreased ALB and increased LA and calcium-phosphorus product were the independent risk factors for PH in PD patients.

Key words: Peritoneal dialysis, Pulmonary hypertension, Influential factor