Abstract: Refractory hypertension (RFH) is a common manifestation, which is a serious threat to the prognosis and quality of life in uremic patients. Many studies have revealed that water/sodium retention, activation of renin-angiotensin system, excessive excitement of sympathetic nerve, and other participating factors are the main factors for uremic RFH. Strict control of water and sodium intake, judiciously using hemodialysis for antihypertension, and comprehensive application of antihypertensives and other auxiliary drugs are the measures to treat RFH. Percutaneous transluminal renal artery stenting for patients with local renal artery stenosis, and renal denervation for those refractory to drug treatment may be required.

Key words: Uremia, Refractory hypertension, Treatment