Abstract: Objectives The purpose of this retrospective cohort study was to investigate the long-term renal outcome in women with preeclampsia. Methods In this retrospective cohort study, patients with preeclampsia between 2005 and 2011 and hospitalized in Obstetric Department of Peking University Third Hospital were recruited. The recovery of renal function and blood pressure after delivery was observed. The risk factors for persistent renal damage and hypertension after delivery were analyzed. Results ①The postpartum urinary protein was negative at discharge from the hospital in 39.4% (121/307) preeclampsia patients. Proteinuria persisted after 3 months in 49.2% (151/307) preeclampsia patients. ② Until the latest follow-up study, 5 patients (5/307, 1.6%) still had proteinuria, 18 patients (18/307, 5.9%) still had hypertension, and all participants had normal renal function. ③Multivariate logistic regression showed that the risk factors for continuous proteinuria after delivery for 3 months were prepartum urinary protein ≥3.0 g/24h (HR=3.560, 95% CI 1.694～7.482, P=0.001), prepartum systolic blood pressure (SBP) ≥155 mmHg (HR=2.031, 95% CI 1.049～3.934, P=0.036) and severe preeclampsia (HR=2.580, 95% CI 1.166～5.708, P=0.019); the risk factors for long-term hypertension were prepartum SBP ≥160 mmHg (HR=7.875, 95% CI 2.081～29.794, P=0.002) and hemoglobin level ≥123 g/L (HR=3.517, 95% CI 1.170～10.577, P=0.025). We could not find out the risk factors for persistent proteinuria due to the small samples. Conclusions The long-term renal outcome was optimistic in most preeclampsia women. Proteinuria (5/307, 1.6%) and hypertension (18/307, 5.9%) persisted in only a few patients. The risk factors for continuous proteinuria after delivery for 3 months were prepartum urinary protein ≥3.0 g/24h, prepartum SBP ≥155 mmHg and severe preeclampsia. The risk factors for long-term hypertension were prepartum SBP ≥160 mmHg and hemoglobin level ≥123 g/L. Longer follow- up period and larger samples are required to find out the risk factors for long-term renal outcome in preeclampsia women.

Key words: Preeclampsia, proteinuria, blood pressure, follow-up