Abstract: 【Abstract】Objective To assess the effect of different renal replacement therapy on cognitive function in patients with end-stage renal disease (ESRD). Methods We searched the databases of CBM, CNKI, VIP, PubMed, Medline, Embase, Cinahl and PsycARTICLES from inception to March 31, 2018 for English and Chinese literature including cross-sectional studies, cohort studies and case-control studies that studied the effect of different renal replacement therapy on cognitive function in ESRD patients. Literature screening, data extraction and bias assessment of all eligible studies were conducted independently by two reviewers. Metaanalysis was conducted by using the RevMan 5.3 software. Results A total of 18 studies which included 1, 787 participants were analyzed. Meta-analysis showed that ①the cognitive function score of hemodialysis patients was lower than that of peritoneal dialysis patients (SMD=-0.660, 95% CI -1.020~-0.290, P＜0.001); ② the cognitive function score of hemodialysis patients was lower than that of renal transplantation patients (SMD=-1.510, 95% CI -2.990~-0.030, P=0.050); and ③the cognitive function score of peritoneal dialysis patients was lower than that of renal transplantation patients (SMD=-2.160, 95% CI -4.220~-0.090, P=0.040). Conclusion Our results suggested that the cognitive function was different in ESRD patients treated by different renal replacement therapy. Cognitive function score of renal transplantation patients was greater than that of hemodialysis and peritoneal dialysis patients, and the score of peritoneal dialysis patients was greater than that of hemodialysis patients.

Key words: Chronic kidney disease, End-stage renal disease, Renal replacement therapy, Hemodialysis, Peritoneal dialysis, Renal transplantation, Cognitive function,  , Meta-analysis