Abstract: 【Abstract】Objective To investigate the relationship between different parathyroid hormone level and clinical cardiovascular events in the consecutive dialysis patients with secondary hyperparathyroidism after parathyroidectomy，and to explore the reasonable control range of postoperative iPTH level. Method Sixty patients undergoing maintenance hemodialysis with secondary hyperparathyroidism after parathyroidectomy were divided into three groups: iPTH < 60 pg/ml, iPTH 60-150 pg/ml and iPTH 150-300 pg/ml. Statistical analysis of the relevant data. Result The level of Ca,P,Ca×P,iPTH,CCS of the patients after parathyroidectomy were lower than those before operation (P=0.018, P=0.034, P =0.023, P =0.007, P =0.006). Postoperatively, as the iPTH gradually decreases ,the coronary calcification score gradually increases,the difference had statistical significance (P=0.014, P =0.026). but the cardiovascular events in group iPTH < 60 pg/ml were significantly higher than the above two groups, the difference had statistical significance (P =0.023, P =0.037, P =0.014, P =0.046). Conclusion Coronary artery calcification and hyperphosphatemia can be significantly alleviated after parathyroidectomy in CKD5 patients with secondary hyperparathyroidism. However, too low iPTH can significantly increase the incidence of cardiovascular events and mortality in postoperative patients.

Key words: secondary hyperparathyroidism, parathyroidectomy, coronary artery calcification, parathyroid hormone