Abstract: 【Abstract】Magnesium is an important ion in the human body and participates in many metabolic processes including bone metabolism, nerve conduction, heart rhythm and vasoconstriction. Studies have focused on calcium, phosphorus, parathyroid hormone and abnormal bone metabolism in patients with chronic kidney disease (CKD) and end stage renal disease (ESRD). Recent studies find that dialysis patients with hypomagnesemia have increased risks of vascular calcification, cardiovascular disease and all-cause mortality rate. ESRD patients, especially those complicated with diabetes, hyperphosphatemia, hypercalcemia and uremia environment, have high risk of calciphylaxis. In this review, we introduce the correlation and mechanism between blood magnesium level and vascular calcification and calciphylaxis in CKD patients.

Key words: Magnesium, Vascular calcification, Calciphylaxis, Chronic kidney disease