Abstract: 【Abstract】Objective To observe the clinical application of automated peritoneal dialysis (APD) in urgent-started peritoneal dialysis patients. Methods We recruited 54 end-stage renal disease (ESRD) patients with newly placed peritoneal tubes and treated in the Second Affiliated Hospital of Hebei Medical University. They were divided into manual exchange peritoneal dialysis group (MPD group) and APD group. The general situation, biochemical indicators, average daily dialysis volume, ultrafiltration volume, urine output and catheter complications were recorded. They were observed for one week. Results ①There were no significant differences in baseline parameters between the two groups. ②For patients in the two groups after one week of the treatment, systolic blood pressure, blood urea nitrogen, serum creatinine and phosphorus were decreased (For APD group, t=2.481, 6.911, 3.191 and 3.603 respectively; P=0.023, ＜0.001, 0.005 and 0.002 respectively. For MPD group, t=2.168, 7.661, 3.363 and 4.043 respectively; P=0.038, ＜0.001, 0.002 and 0.000 respectively), and hemoglobin, serum calcium and sodium were increased (For PAD group, t=2.351, 3.008 and 2.289 respectively; P=0.030, 0.007 and 0.034 respectively. For MPD group, t=2.352, 2.933 and 2.691 respectively; P=0.025, 0.006 and 0.011 respectively) as compared to the baseline values. ③During the dialysis treatment, appetite improved more in APD group than in MPD group (t=2.711, P=0.012). ④There were no catheter complications in both groups. ⑤Ultrafiltration volume, urine volume, body mass and blood urea nitrogen improved more in APD group than in MPD group (t=4.067, 2.173, 2.093 and 3.257 respectively; P＜0.001, 0.035, 0.044 and 0.002 respectively). Conclusions In ESRD patients required urgent-started peritoneal dialysis, APD method had the advantages in toxin clearance, symptom improvement and compliance with the dialysis method.

Key words: Peritoneal dialysis, Automation, Manual exchange, Urgent-start, End-stage renal disease