Chinese Journal of Blood Purification ›› 2019, Vol. 18 ›› Issue (08): 564-567.doi: 10.3969/j.issn.1671-4091.2019.08.014

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An in vitro study about the remaining rate of sealing fluid in central venous catheters

  

  1. 1Department of Nephrology, Peking University People’s Hospital, Beijing 100044, China
    2Department of Nephrology, Zhengzhou Traditional Chinese Medicine Hospital Affiliated to Henan University of Traditional Chinese Medicine, Zhengzhou 150007, China
    3Department of Nephrology, Yuncheng Tongde Hospital, Yuncheng 044000, China
    4Department of Nephrology, Beijing Boai Hospital, Beijing 100068, China
  • Received:2019-01-07 Revised:2019-05-28 Online:2019-08-12 Published:2019-08-15

Abstract: 【Abstract】Objective To observe the gradient concentration of sealing fluid sealed in central vein catheters for 0-96 hours, and to summarize the concentration-time changing rule of the sealing fluid. Methods A catheters was placed vertically in a flask containing 1,000ml reverse-osmosis water of secondary grade. The scaled volume of sealing fluid was injected into the venous end of the catheter. Samples were collected from tip to tail of the catheter in six parts, and the procedure was repeated 10 times. The average concentration was calculated, the concentration-time curve was drawn, and the parameters were obtained by fitting the four-parameter model curve. Results Immediately after tube closure, the concentration remained in the tip segment was 15.8 ± 0.8mmol/L, rapidly decreased to 9.9 ± 0.9mmol/L in 5 minutes, then slowly decreased to 0.7 ±0.1mmol/L after 96 hours. The concentration remained in the second segment gradually decreased from 22.4±0.6mmol/L immediately after tube closure to 2.7±0.4mmol/L after 96 hours. The decline rate slowed down along the first to sixth segments. The concentration of remained sealing fluid was similar in the fourth, fifth and sixth segments after 96 hours. Fitting equation Y=(A- D)/[1 + (T/C)B] +D can mesh with the propellant curve (R2>90). Conclusion Immediately after sealing, the sealing fluid at the tip of the tube lost and quickly and further lost within 5 minutes, associated with significant decrease of sealing fluid concentration. According
to the fitting equation, the suitable concentration and effective time of sealing fluid can be calculated and a reasonable sealing strategy can be worked out.

Key words: Central venous catheter, Sealing fluid, Remaining rate

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