【Abstract】Objective We analyzed the common problems in the manuscripts that have to be revised by authors at the processing stage in the Editorial Board of Chinese Journal of Blood Purification, in order to improve the formats of the papers, to understand the requirements for submission of manuscripts by authors, and to ensure a high quality of the journal. Methods The causes that lead to the return of the manuscripts for revision by authors at the processing stage in the period from Jan. 2018 to Jun. 2018 were analyzed through online search for the processing courses in the editing system of Chinese Journal of Blood Purification. Results A total of 105 manuscripts were processed for publication in this period; the manuscripts were sent back for revision for a total of 100 times with a total of 216 editing problems, of which the top three were faults in figure and/or table design, word expression and numerical data processing (24.54%), misuse or omitted use of statistics (21.76%), and errors in medical terminology applications (20.37%). Other causes for the revision included wrong reference format (16.20%), the absence of information about the names of authors and/or corresponding authors and their affiliations (10.19%), and manuscripts with inappropriate arrangement of their contents, too more words and out of focus on its objective and conclusion (6.94%). Conclusion Many faults were present in most manuscripts at the time of submission. These manuscripts usually had the shortcomings in design of figures and tables, statistical analyses, expression of medical terminology, and reference format, leading to the return of the manuscript to authors for revision at the processing stage. Therefore, authors are expected to avoid these shortcomings and to improve their writing ability before submission. Staff members in the Editorial Board are ready to help authors find out and correct these shortcomings to pursue a high quality of Chinese Journal of Blood Purification.