Abstract: 【Abstract】Objective To investigate the status of uncertainty in illness with maintenance hemodialysis (MHD) and its relationship with depression and hope. Methods Self-made questionnaire, Chinese version of Mishel disease uncertainty scale, depression self-rating scale, and Herth hope scale were used to investigate 180 MHD patients who met the inclusion criteria. Results The average total scores were 74.23±7.64 for Chinese version of Mishel disease uncertainty scale, 53.04±9.59 for depression self-rating scale, and 32.33±3.05 for Herth hope scale. The total score of uncertainty in illness was positively correlated with the total score of depression (r=0.429, P<0.001), and was negatively correlated with the total score of hope (r=-0.348, P<0.001). Multiple linear regression analysis showed that the level of depression could positively predict the level of uncertainty in illness (β=0.170, P<0.001), and the level of hope could negatively predict the level of uncertainty in illness (β=-0.398, P<0.001). Conclusions MHD patients had a higher level of uncertainty in illness, which was related to the levels of depression and hope.

Key words: Maintenance hemodialysis, Uncertainty in illness, Depression, Hope