Abstract: 【Abstract】Anemia is one of the most common complications in chronic kidney disease (CKD) patients. Cardiovascular disease is a major cause of mortality in CKD patients at stage 3～5. Renal anemia can aggravate the multisystem organ damages and is an important independent risk factor for cardiovascular complications in CKD patients. Therefore, management of renal anemia must be emphasized to improve the cardiovascular outcome in CKD patients. This article reviews cardiovascular safety in CKD patients with anemia from the view point of renal anemia and its treatment.

Key words: Anemia, Chronic kidney disease, Cardiovascular disease, Roxadustat