Abstract: 【Abstract】Objective To explore the clinical characteristics of obstructive sleep apnea (OSA) in patients with maintenance hemodialysis (MHD). Methods Forty- two MHD patients were enrolled for night- time sleep breathing monitoring. They were divided into the OSA group (n=31) and the non-OSA group (n=11). The OSA group was further divided into a mild group (n=16) and a moderatEsevere group (n=15). The clinical characteristics between the four groups were compared. Results ①The incidence of left ventricular concentric hypertrophy was higher in OSA group than in non-OSA group (χ2=12.129, P=0.001). ②The daily sodium bicarbonate intake was higher in OSA group than in non-OSA group (t=-2.383, P=0.022), and was higher
in moderatEsevere OSA group than in mild OSA group (t=- 2.448, P=0.021). Conclusion Clinicians should pay attention to the early diagnosis and prevention of OSA in MHD patients. Unlike the OSA in general population, serum CO2CP is negatively correlated with the degree of OSA in MHD patients, suggesting that clinicians should concern about the amount of sodium bicarbonate to correct acidosis.

Key words: Sleep apnea, Maintenance hemodialysis, Left ventricular hypertrophy, Carbon dioxide binding capacity