Abstract: 【Abstract】Objective To explore the relationship between serum levels of fibroblast growth factor- 23(FGF- 23) and soluble klotho (sKL) and cardiac valve calcification (CVC) in maintenance hemodialysis (MHD) patients. Methods A total of 100 MHD patients treated in the Blood Purification Center of Laigang Hospital were enrolled in this study as the observation group. The serum concentrations of FGF-23 and sKL were measured by enzyme-linked immunosorbent assay. CVC was detected by color Doppler ultrasonography. Results The incidence of CVC and serum level of FGF-23 were higher in observation group than in control group (t=8.820 and 16.642 respectively; P<0.001), while serum level of sKL was lower in observation group than in control group (t= -2.583, P=0.012). The higher levels of serum phosphorus and serum FGF-23 were the independent risk factors for CVC in MHD patients (OR = 2.375 and 1.642 respectively; 95% CI = 1.527 ～ 3.884 and 1.232 ~ 1.912 respectively; P<0.001 and 0.023 respectively). The higher level of sKL was a protective factor for CVC (OR=0.334, 95% CI=0.044~0.621, P＜0.05). Conclusion Serum levels of FGF-23 and sKL were the independent influencing factors for CVC in MHD patients. Therefore, combined detection
of serum FGF-23 and sKL can be used to predict CVC in MHD patients.

Key words: Maintenance hemodialysis, Cardiac valvular calcification, Fibroblast growth factor 23, Soluble Klotho protein