Abstract: 【Abstract】Objective To explore the effect of loop diuretic on the fluid load of maintenance hemodialysis (MHD) patients with residual renal function. Methods Twenty- five MHD patients with residual renal function were enrolled and given the titration dose of furosemide tablets. 24-hour urine output(24hUO), urine electrolytes, blood biochemical tests and home blood pressure were measured at three time points: before the use of furosemide tablets (furosemide 0, F0), 1 month after 100mg treatment (furosemide 100mg, F100mg) and 1 month after 200mg treatment (furosemide 200mg, F200mg). Bioimpedance analysis (BIA) is used to measure body composition at two time points (F0 and F200mg), including overhydration (OH) and extracellular water
(ECW). Results There were significant differences in home systolic blood pressure [F0: 151.6±17.9, F100mg: 150.8±18.5, F200mg: (146.5±12.3)mmHg, P=0.048] and home diastolic blood pressure [F0: 84.4±8.1, F100mg: 81.9±6.4, F200mg: (81.6± 7.4)mmHg, P=0.020] among three time points. There were significant differences in 24hUO [F0: 626±567, F100mg:689±577, F200mg:759±699ml, P=0.030] between three time points, which showed an increasing trend of urine volume. There were significant differences in both OH [2.47±1.34 vs. (2.15±1.36L), P=0.049] and ECW [16.62±2.67 vs. (16.10±2.89)L, P=0.015] between the two time points of F0 and F200mg. Conclusion The use of furosemide tablets in MHD patients with residual renal function can increase urine volume and improve fluid load and blood pressure.

Key words: Loop diuretic, Residual renal function, Maintenance hemodialysis, Urine volume, Fluid load