Abstract: 【Abstract】Objective To investigate the incidence of vitamin D deficiency (VDD) in female adolescents with iron deficiency anemia (IDA) and the correlation of VDD with iron metabolism. Methods A total of 80 female adolescents admitted to the Outpatient Department of Lianyungang First People's Hospital in the period from Jan. 2019 to Dec. 2019 were enrolled in this study. Among them, 50 IDA cases were assigned as the IDA group, and 30 healthy women were recruited as the control group. The incidence of VDD was analyzed in IDA group. The iron metabolism indexes including serum iron, serum ferritin and total iron binding capacity (TIBC) as well as serum vitamin D levels were compared between the two groups. The iron metabolism indexes were also compared in IDA group with different serum vitamin D levels. The correlation between serum vitamin D level and iron metabolism indexes in IDA group was analyzed by Pearson's correlation. Results There were significant differences in body mass index (BMI), hemoglobin, mean corpuscular volume (MCV), hematocrit, serum iron, serum ferritin, TIBC and serum vitamin D between IDA group and control group (t=2.096, P=0.039; t=11.856, P＜0.001; t=7.591, P＜0.001; t=4.194, P＜0.001; t=12.492, P＜0.001; t=12.572, P＜0.001; t=3.152, P=0.002; t=3.626, P=0.001). There were 21 cases (42%) and 5 cases (16.67%) of VDD in IDA group and control group respectively (χ2=5.485, P=0.019). Pearson's correlation analysis showed that there were no correlations between serum vitamin D level and serum ferritin, TIBC(r=-0.081, P=0.658; r=0.029, P=0.883; r=0.141, P=0.394). In IDA group, TIBC and serum vitamin D were significantly different between patients with vitamin D＜30 nmol/L and those with vitamin D＞30 nmol/L (t=2.244, P=0.029; t=12.993, P＜0.001). Conclusion The incidence of VDD in female adolescents with IDA was higher than that in healthy controls. However, serum vitamin D level had no significant correlation with iron metabolism indexes.

Key words: Iron deficiency anemia, Vitamin D deficiency, Adolescent, Female, Iron metabolism