Abstract: 【Abstract】Objective To investigate the present status and related factors about the knowledge and behavior of chronic kidney disease- mineral and bone disorder (CKD- MBD) in maintenance hemodialysis (MHD) patients in order to provide the evidence for the improvement of intervention strategies. Methods A total of 303 MHD patients were investigated cross- sectionally using the general data questionnaire and the knowledge and behavior of CKD-MBD questionnaire. Results The score of knowledge about CKD-MBD was 21.21±10.14 and the score index was 46.11%; the behavior score was 99.43±8.22 and the score index was 82.86%. Our data indicate that the knowledge is affected by education (β=0.463, P<0.001), age (β=-0.243, P< 0.001), the amount of the medications the patients took (β=-0.211, P<0.001), and dialysis time (β=0.160, P< 0.001). The factors regulating the patients’behavior include gender (β=0.245, P<0.001), the amount of medications the patients took (β=-0.193, P<0.001), age (β=0.177, P=0.00), and complications (β=0.169, P=0.002). Conclusion The knowledge and behavior of CKD-MBD were insufficient and were affected by multiple factors in MHD patients. To improve the knowledge and behavior of CKD-MBD in MHD patients, nurses must adopt the interventions individually based on these factors.

Key words: Hemodialysis, Mineral and bone disorder, Knowledge, Behavior