Abstract: 【Abstract】Objective To investigate the effect of continuous renal replacement therapy (CRRT) in the treatment of elderly patients with refractory heart failure and its effect on serum levels of C reactive protein (CRP), galectin-3 (Gal-3), N-terminal pro-brain natriuretic peptide (NT-proBNP), heart fatty acid binding protein (H-FABP) and Nexilin. Methods We recruited 84 elderly patients with refractory heart failure admitted to our hospital from June 2016 to February 2018, and randomly divided them into study group (n=42) and control group (n=42). While all patients received the conventional treatment, patients in study group were also treated with CRRT. Left ventricular ejection fraction(LVEF), stroke volume(SV), left ventricular end-diastolic diameter (LVEDD), maximum mitral flow velocity E-peak/A-peak (E/A), serum levels of CRP, Gal-3, NTproBNP, H-FABP and Nexilin, and clinical effects were compared before and after CRRT between the two groups. Results After the treatment, LVEF, SV and E/A became higher in study group than in control group (t=3.081, 4.131 and 3.043 respectively; P=0.003, 0.000 and 0.003 respectively); LVEDD and the serum levels of CPP, Gal-3, NT-proBNP, H-FABP and Nexilin were lower in study group than in control group (t=-3.520, -7.468, -6.315, -5.008, -4.133 and -5.361 respectively; P=0.001, 0.001,＜0.001,＜0.001,＜0.001 and＜0.001 respectively). Clinical effects were also better in study group than in control group(Z=-2.012, P=0.044). Conclusion CRRT is better than the conventional therapy in the treatment of elderly patients with refractory heart failure. CRRT can also significantly reduce the serum levels of CRP, Gal-3, NT-proBNP, H-FABP and Nexilin.

Key words: Continuous renal replacement therapy, Refractory heart failure, C-reactive protein, Galectin-3, N-terminal pro-brain natriuretic peptide, Heart fatty acid binding protein, Nexilin