Abstract: 【Abstract】Objective To investigate the relationship between neutrophils-lymphocytes ratio (NLR), nutritional status and abdominal aortic calcification (AAC) in maintenance hemodialysis (MHD) patients, and to analyze the risk factors of AAC. Methods MHD patients treated in the Blood Purification Center of the Affiliated Hospital of Xuzhou Medical University from 2019 to 2020 were selected. The clinical data and laboratory examination results of patients were collected, and the AAC of patients was examined by abdominal lateral X-ray film. The geriatric nutritional risk index (GNRI) was used to evaluate patients’nutritional status. According to whether abdominal aortic calcification occured, the patients were divided into non- calcification group and calcification group. The differences of indices between the two groups were compared, and binary Logistic regression analysis was used to explore the risk factors of AAC. Results A total of 72 patients with MHD were included, divided into calcification group (n= 37) and non-calcification group (n=35). Compared with the non-calcified group, patients in calcification group were older, with higher proportion of diabetes mellitus, and with higher parathyroid hormone (PTH), C-creative protein (CRP) and NLR, lower albumin, GNRI (P＜0.05). Correlation analysis showed that AAC was positively correlated with age, PTH, CRP and NLR, but negatively correlated with Alb and GNRI (P＜0.05). Logistic regression analysis showed that age, diabetes mellitus, lower albumin and higher NLR were independent risk factors for abdominal aortic calcification.Conclusions NLR and malnutrition status are associated with AAC in patients with MHD. Old age, diabetes mellitus, lower albumin and higher NLR are independent risk factors for abdominal aortic calcification.

Key words: maintenance hemodialysis, neutrophils-to-lymphocytes ratio, Geriatric nutritional risk index, Abdominal aortic calcification