Abstract: 【Abstract】Objective To investigate the effects of exercise therapy on microinflammatory status and hyperhomocysteinemia
(HHcy) in maintenance hemodialysis (MHD) patients. Methods A total of 90 MHD patients were enrolled in this study. They were randomly divided into exercise group and control group. Patients in the exercise group performed an intradialytic exercise program for 20～35 minutes during the first 2 hours in a dialysis session, and the intradialytic exercise was carried out 3 dialysis sessions per week for 6 months. Serum interleukin- 6 (IL- 6), procalcitonin (PCT), C- reactive protein (CRP) and homocysteine (Hcy) levels
were measured in both groups before the treatment and after the treatment for 6 months. Results The levels of IL-6, PCT, CRP and Hcy in the exercise group were lower than those in the control group after 6 months, and the differences were statistically significant (P<0.05). In the exercise group, the levels of IL-6, PCT, CRP and Hcy decreased after 6 months of exercise compared with those before exercise, and the differences were statistically significant (P<0.05). Conclusions Intradialytic exercise therapy had significant effects on microinflammation and HHcy in MHD patients.

Key words: Maintenance hemodialysis, Exercise therapy, Microinflammation state, Hyperhomocysteinemia