Abstract: 【Abstract】Objective To evaluate the outcome and its influence factors of peritoneal dialysis (PD) patients complicated with type 2 diabetes mellitus. Methods The PD patients diagnosed with type 2 diabetes at the beginning of PD and treated in our center from May 1, 2015 to May 1, 2020 were enrolled in this study. Their clinical data and outcome information were collected. The end-point events were analyzed and the influence factors for the withdrawal of PD were then identified. Results A total of 113 eligible subjects were recruited, including 70 males (61.95%) and 43 females (38.05%) with an average age of 60 (54, 68) years old and an average PD period of 27 (15, 48) months. Defined end events that led to the withdrawal of PD developed in 47 patients (41.59%), of which 17 cases (15.4%) died and 30 cases (26.55%) transferred to hemodialysis. Univariate and multivariate COX analyses showed that obesity (HR=2.131, 95% CI:1.123～4.045, P=0.021) and the time of starting PD (HR=1.863, 95% CI: 0.872～3.243, P=0.055) were the independent risk factors for survival of the PD patients. In the survival analysis, the median PD duration was 50 (25, 123) months in the 113 patients; the median PD duration was 42 (20, 71) months in obese patients, significantly shorter than that of 85 (34, 123) months in non-obese patients (c2=5.750, P=0.016). The median PD duration was 73 (33, 120) months in late dialysis patients, significantly longer than that of 41 (20, 58) months in nonlate dialysis patients (c2= 4.501, P=0.034). Conclusion Obese PD patients with type 2 diabetes have a relatively high risk of withdrawal from PD.

Key words: Peritoneal dialysis, Type 2 diabetes mellitus, Retrospective study, Outcome, Risk factor