Abstract: 【Abstract】Objectives To investigate the correlation between whole blood trace elements and serum parathyroid hormone (PTH) in maintenance hemodialysis (MHD) patients. Method This was a cross-section and singlEcenter study. A total of 153 MHD patients treated during September 2019 in our center were enrolled in this study. Their clinical data and drug usage were collected. Laboratory parameters and blood trace elements were measured before dialysis. According to serum PTH level, patients were divided into high PTH group (PTH≥300pg/ml, n=46) and the low PTH group (PTH<300pg/ml, n=107). Clinical characteristics were
compared between the two groups. Univariate and multivariate logistic regressions were utilized to analyze the factors relating to the high PTH level. Results Compared with the patients in the low PTH group, those in the high PTH group had higher prEdialysis levels of serum calcium, phosphorus, creatinine, alkaline phosphatase, albumin, prealbumin, ferritin and whole blood lead, but had no significant differences in other trace elements. Multivariate binary logistic regression showed that higher levels of serum calcium and phosphorus, use of calcitriol and blood lead>44.3μg/L were independently correlated with the higher serum PTH. Conclusion
Whole blood lead >44.3μg/L was independently correlated with the serum PTH≥300pg/ml in MHD patients.

Key words: Maintenance hemodialysis, Parathyroid hormone, Whole blood lead, Whole blood trace elements