Chinese Journal of Blood Purification

Chinese Journal of Blood Purification ›› 2021, Vol. 20 ›› Issue (03): 189-192.doi: 10.3969/j.issn.1671-4091.2021.03.010

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Research progress in the role of klotho in vascular calcification in chronic kidney disease

  

  1. 1Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Traditional Chinese Medicine Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine; Key Laboratory of Liver and Kidney Diseases, Ministry of Education; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China
  • Received:2020-10-15 Revised:2020-12-09 Online:2021-03-12 Published:2021-03-12
  • Contact: Chao-yang chaoYe E-mail:yechaoyan963@126.com

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Abstract: 【Abstract】The incidence of chronic kidney disease (CKD) is increasing progressively. CKD patients are frequently accompanied with bone mineral metabolism disorder (CKD-MBD) along with the decline of renal function. CKD-MBD is mainly manifested by abnormal calcium and phosphorus metabolism, secondary hyperparathyroidism and vascular calcification (VC), leading to the higher incidence of cardiovascular disease and the negative impacts on quality of life and prognosis of the patients. Recent studies have shown that Klotho is an anti-aging gene, which is mainly expressed in kidney and protects kidney through the inhibition of renal fibrosis and regulation of calcium and phosphorus metabolism. This review focuses on recent research progress in the role of Klotho on VC.

Key words: Vascular calcification, Klotho, FGF23, Chronic kidney disease

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