Abstract: 【Abstract】Objective To study the clinical characteristics, prognosis and risk factors of patients with heart failure (HF) receiving continuous renal replacement therapy (CRRT). Methods The clinical data of HF patients treated with CRRT in Beijing Anzhen Hospital from January 2008 to December 2019 were recruited. Their clinical characteristics and risk factors for death in hospital were analyzed. Results A total of 85 patients with complete data were enrolled in this study. The overall mortality rate in hospital was 35.3% (30/85), 45.9% (39/85) patients could get rid of CRRT, and 18.8% (16/85) patients were dependent on maintenance dialysis. Logistic regression analysis was performed based on the comparison of death in hospital and survival patients using the factor of P<0.05. The independent risk factor for overall death was ejection fraction (EF) value <40% (OR: 4.610, 95% CI: 1.323～16.058, P=0.016), chronic HF history (OR: 8.448, 95% CI: 2.071～34.464, P=0.003), and CRRT start time (OR: 4.114, 95% CI: 1.224～13.830, P=0.022). The hospital mortality of HF patients with reduced ejection fraction (HFrEF) and HF patients with preserved ejection fraction (HFpEF) was 44.9% (22/49) and 22.2% (8/36), respectively, which was statistically different (F=4.673, P=0.031). Conclusion Early initiation of CRRT may reduce hospital mortality. History of chronic HF, frequent hypotension events during CRRT and the application of vasoactive drugs were the risk factors for mortality in HF patients. The mortality of HFrEF patients receiving CRRT was significantly higher than that of HFpEF patients.

Key words: Heart failure, Ejection fraction, Continuous renal replacement therapy