Abstract: 【Abstract】Objective To predict prognosis of the end stage renal disease (ESRD) patients with maintenance hemodialysis (MHD) by using albumin/C-reactive protein ratio (ALB/CRP), red blood cell distribution width (RDW), serum uric acid (SUA) and integration of the three indicators. Methods A total of 265 ESRD patients treated with MHD in the First Affiliated Hospital of Air Force Medical University were enrolled in this study. After 6 months of MHD, they were divided into death group (n=31) and survival group (n=234) according to their survival status. Clinical data, and ALB/CRP, RDW and SUA levels were compared between the two groups. Logistic regression was conducted to analyze the prognostic factors. Receiver operating characteristic curve (ROC) was used to estimate the prognostic values of the three indicators and the integrated value of the three indicators. Results Among the 265 ESRD patients, 31 died in the 6 months of MHD, with a mortality rate of 11.70%. After 3 months and 5 months of MHD, ALB/CRP and SUA were significantly decreased, and RDW was significantly increased in both groups; ALB/CRP and SUA were lower (F=18.261, 20.608, P＜0.001) and RDW was higher (F=16.256, P＜0.001) in the death group than in the survival group; the changes of ALB/CRP (OR=0.507, 95% CI: 0.315～0.817; OR=0.610, 95% CI: 0.405～0.918), SUA (OR= 0.391, 95% CI: 1.264～1.417; OR=0.445, 95% CI: 0.205～0.964) and RDW (OR=1.338, 95% CI: 1.264～ 1.417; OR=1.439, 95% CI: 1.355～1.529) were the influencing factors for prognosis of the ESRD patients with MHD (P＜0.001); After 3 and 5 months of MHD, the area under the curve (AUC) of ALB/CRP, RDW and SUA levels to predict prognosis of the ESRD patients with MHD was＞0.7; after 5 months of MHD, the AUC of the integrated value of the three indicators to predict prognosis became bigger (0.890). Conclusion ALB/CRP, RDW and SUA are significantly correlated with the prognosis of ESRD patients with MHD. The integration of the 3 indicators has a higher value to predict prognosis of these patients.

Key words: End stage renal disease, Maintenance hemodialysis, Albumin to C-reactive protein ratio,  Red blood cell distribution width, Serum uric acid