Chinese Journal of Blood Purification

Chinese Journal of Blood Purification ›› 2021, Vol. 20 ›› Issue (06): 382-386.doi: 10.3969/j.issn.1671-4091.2021.06.006

Previous Articles     Next Articles

Correlation between vitamin D level and cardiac function in hemodialysis patients 

  

  1. 1Department of Nephrology, Chinese PLA Strategic Support Force Medical Center, Beijing 100101, China;  2Internal Medicine Department, Chaoyang First Sanitarium for Retired Cadres of Beijing Garrison of PLA, Beijing 100026, China
  • Received:2021-01-28 Revised:2021-03-25 Online:2021-06-12 Published:2021-06-17

PDF

709

Abstract: 【Abstract】Objective To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and cardiovascular function in hemodialysis patients. Methods This was a cross-sectional study. Serum 25(OH)D levels were determined from 109 hemodialysis patients treated in the Dialysis Center of the PLA Strategic Support Force Medical Center. Clinical data and cardiac ultrasound results of the 109 hemodialysis patients were collected. Correlation and multivariate regression analyses were used to evaluate the relationship between serum 25(OH)D level and cardiovascular function. Results The average value of 25(OH)D was
50.39±22.74 nmol/L in the hemodialysis patients, in which 65 patients (59.6%) were identified as 25(OH)D deficient (≤50nmol/L). By comparing between 25(OH)D normal group and 25(OH)D deficient group, there were no significant differences in B-type natriuretic peptide (BNP), high- sensitivity C-reactive protein (hs-CRP), intact parathyroid hormone (iPTH), hemoglobin, left ventricular mass (LVM), left ventricular mass index (LVMI), ejection fraction (EF), fraction shortening (FS), left ventricular internal dimensions at end-diastole (LVIDd), posterior wall thickness at end- diastole (PWTd), septal wall thickness at end- diastole (SWTd), left ventricular end diastolic diameter (LVED), systolic left ventricular volume (LVES) and the ratio of mitralwave E peak velocity to A peak velocity (e/a), but there was a significant difference in the ratio mitral-wave E peak velocity to mitral annulus velocity E’(e/e ́) (t=2.495, P=0.001). Spearman analysis showed that 25(OH) D was negatively correlated with e/e ́ (r=-0.272, P=0.004). Multivariate regression showed that 25(OH)D was an independent correlation factor for e/e´(β=-0.115, 95% CI: -0.129～-0.009, P=0.010). Conclusions Serum 25(OH)D level was lower in maintenance hemodialysis patients. 25(OH)D level was independently and negatively correlated with left ventricular diastolic function.

Key words: Serum 25-hydroxyvitamin D, Hemodialysis, Cardiac diastolic function

CLC Number: