Abstract: 【Abstract】Objective A systematic review of the prevalence and influencing factors of sarcopenia in maintenance hemodialysis (MHD) patients in Asia. Methods Computer search of PubMed, Embase, Web of Science, Cochrane Library, CNKI, China Biomedical Literature Database, VIP and Wanfang Database from the establishment of the database to October 2020 for the prevalence and influencing factors of sarcopenia in maintenance hemodialysis (MHD) patients in Asia was conducted. Stata 15.1 software was used for meta analysis. Results A total of 10 articles were enrolled, including 1,830 subjects, and the quality of the literature was medium to high. Meta analysis showed that the prevalence of sarcopenia in MHD patients in Asia was 33% (95% CI 0.227～0.428), and the prevalence of sarcopenia in MHD patients in China was 32% (95% CI 0.198～0.437). The influencing factors of sarcopenia included age (OR=0.850, 95% CI 0.630～1.070, P＜0.001), dialysis duration (OR=0.396, 95% CI 0.090～0.701, P= 0.011), modified quantitative subjective global nutrition evaluation assessment (MQSGA) score (OR=0.886, 95% CI 0.694～1.077, P＜0.001) and serum phosphorus (OR=-0.613, 95% CI -0.877～-0.349, P＜0.001). Conclusion The prevalence of sarcopenia in
MHD patients in Asia was high. Older age, longer dialysis age, malnutrition, and lower serum phosphorus level were the risk factors for sarcopenia in MHD patients. Sarcopenia in MHD patients should be treated as early as possible.

Key words: Sarcopenia, Hemodialysis, Influence factor, Meta analysis