Abstract: 【Abstract】Objective To identify the risk factors on the efficacy of plasma exchange in hyperlipidemic pancreatitis patients by Logistic regression. Methods We retrospectively analyzed the clinical data of 58 hyperlipidemic pancreatitis patients who underwent plasma exchange treatment in the Blood Purification Center of Shantou Central Hospital from January 2015 to December 2020. According to the comparison of the abdominal CT results both before and after the plasma exchange, enrolled patients were divided into improved group and progressed group. Compare the clinical data between the two groups. Logistic regression analysis
was performed to analyze the risk factors which affected the imaging progression of hyperlipidemic pancreatitis patients. Results 58 patients recruited in this study, including 47 males and 11 females, mean age was 39.0 ± 8.8 years. There was a significant difference in the TG level of patients before and after plasma exchange treatment (16.7±4.3 mmol/L vs. 6.6±2.8 mmol/L, t= 19.524, P＜0.001). The post-treatment abdominal CT results showed 28 cases (48.3%) in the improved group and 30 cases (51.7%) in the progressed group. Compared with patients in the imaging improvement group, patients in the imaging progressed group had higher serum glucose (t=2.406, P=0.019), a higher proportion of serum amylase＞300 U/L (χ2=4.459, P=0.035), a higher proportion of Balthazar CT grade D/E (χ2=4.351, P=0.037), and higher TG after treatment (t=2.441, P=0.018). Multivariate Logistic regression analysis showed that the independent risk factors affecting the imaging progression of hyperlipidemic pancreatitis included serum amylase＞300u/L (OR=3.781, 95% CI：1.124～12.723, P=0.032), and post- treatment TG (OR= 1.309, 95% CI：1.040-1.646，P=0.022). Conclusion Plasma exchange can significantly reduce the level of blood lipid, and the independent risk factors affecting the imaging progression of hyperlipidemic pancreatitis include serum amylase and post-treatment TG.

Key words: Plasmapheresis, Hyperlipidemic Pancreatitis, Influential Factors