Abstract: 【Abstract】Objective To systematically evaluate the effects of intradialytic exercise on athletic ability and dialysis adequacy in maintenance hemodialysis (MHD) patients. Methods The databases of PubMed, Embase, Web of science, Cochrane Library, CNKI, VIP and WanFang were retrieved from the establishment of the database to July 2020 for the randomized controlled trials of intradialytic exercise. Two investigators screened the literature according to the inclusion and exclusion criteria. After data extraction and quality assessment, the software of RevMan 5.3 was used for meta-analysis. Results A total of 22 studies which included 1,057 participants were analyzed. Meta-analysis showed that the intradialytic exercise group had better outcomes than the control group in 6-minute walk distance (MD=69.070, 95% CI 54.710~83.440, P＜0.001), 10 sit- to- stand- to- sit cycles (SMD=- 0.770, 95% CI~1.170~- 0.380, P＜0.001), peak oxygen uptake (VO2peak) (SMD=0.460, 95% CI 0.070~0.850, P=0.020), and Kt/V (MD=0.090, 95% CI 0.020~0.170, P=0.010). Conclusion Intradialytic exercise can enhance athletic ability and improve dialysis adequacy in MHD patients.

Key words: Hemodialysis, Intradialytic exercise, Athletic ability, Dialysis adequacy, Meta-analysis