Abstract: 【Abstract】Objectives To explore the interaction between intraperitoneal pressure (IPP) and peritoneal transport function changes in peritoneal dialysis (PD) patients. Methods A total of 50 PD patients undergoing peritoneal equilibration test (PET) in the Second Affiliated Hospital, Harbin Medical University during August 2020 to January 2021 were enrolled in this study. Their clinical data were recruited. They were divided into groups based on the results of IPP and PET and the creatinine ratio of dialysate (4 hours)/plasma (D/Pcr). Clinical data and laboratory results were compared between groups. Correlation analyses were also carried
out. Results ①BMI (F=12.442, P=0.023), waist circumference (F=14.090, P=0.001) and D/Pcr (F=4.582, P=0.037) were significantly higher in the high IPP group than in the moderate high IPP but within range group and the low IPP but within normal range group. In addition, BMI (F=3.226, P=0.033) and IPP (F=8.816, P=0.018) were significantly higher in the high transport group than in the high average transport group, the low average transport group and the low transport group. ②Spearman correlation analysis showed that IPP was positively correlated with body weight (r=0.766, P=0.002), BMI(r=0.849, P=0.023), D/Pcr (r=0.658, P=0.037) and waist circumference (r=0.855,P=0.001); D/Pcr was positively correlated with BMI (r=0.636, P=0.033), IPP (r=0.647, P=0.018) and was negatively correlation with HDL (r=-0.121, P=0.013). ③Logistic regression analysis showed that BMI (OR=0.083, 95% CI: 0.485~0.924, P=0.043), body weight (OR=0.796, 95% CI: 0.669~ 946, P=0.010) and waist circumference (OR=0.717, 95% CI: 0.544~0.945, P=0.018) were the independent risk factors for high IPP; BMI (OR=0.696, 95% CI: 0.495~0.979, P=0.037), body weight (OR=0.918,95% CI：0.843~1.000, P=0.049) and IPP (OR=0.728, 95% CI：0.524 ~ 1.010, P=0.047) were the independent risk factors for peritoneal transport function. Conclusions ① IPP and peritoneal transport function were closely related and affected each other. ②BMI, waist circumference and body weight may be the indicators for predicting IPP in PD patients; BMI, IPP and body weight may be used as the indicators for predicting peritoneal transport type in PD patients.

Key words: Peritoneal dialysis, Peritoneal transport function, Intraperitoneal pressure