Abstract: 【Abstract】Multiorgan failure is one of the most frequent causes for death in critically ill patients. Extracorporeal organ supports are now available for the treatment of organ failures. For example, renal replacement therapy, extracorporeal membrane oxygenation, extracorporeal CO₂ removal (ECCO₂R) and extracorporeal liver support have been used as the stand-alone single organ support systems. Considering multiple“crosstalk” interactions between organs, multiple organ support therapy(MOST) can cooperatively support the patients with different organ failures. Combined modules consisting of prEexisted technologies such as renal replacement, albumin-dialysis, ECCO₂R and cytokine elimination are the first step to be considered. Integrated platform
with the capacity to support multiple organs is expected to be developed.

Key words: Extracorporeal organ support, Renal replacement therapy, Albumin dialysis, Hemadsorption, Extracorporeal CO₂ removal