Abstract: 【Abstract】Objective To analyze the association between Kt and the clearance of medium molecular toxin in uremia. Methods We collected the data of high-flux maintenance hemodialysis patients in the dialysis center of Tong Ren Hospital. The target Kt was calculated by the formula: target Kt =1/[0.0069+(0.0237/BSA)]. Calculate the actual Kt according to Kt/V; Univariate analysis was performed for prEdialysis cystatin C level and cystatin C reduction ratio (CCRR). The CCRR was analyzed by multiple linear regression. The analysis was performed by SPSS (Version 22.0). Results Among 56 patients, 31 were males and 25 were females.
The prEdialysis cystatin C was not affected by the characteristics of dialysis patients. Compared with the patients who meet both the target of Kt/V and Kt, the patients who only meet the target of Kt/V had lower CCRR(t=3.394, P =0.001) and higher parathyroid hormone (Z=-2.621, P=0.008). In univariate analysis, there were many factors correlated with CCRR, but after multiple regression analysis, only Kt difference (the actual Kt value - the target Kt value) had a linear correlation with CCRR (β=0.797, P=0.014). Conclusion Cystatin C can be used to evaluate the level of medium molecular toxin in dialysis patients. Kt can be used to evaluate the medium molecular clearance in high-flux hemodialysis patients, to make up the restrictions of Kt/V in accessing adequacy.

Key words: Kt, Cystatin C, High-flux hemodialysis