Abstract: 【Abstract】Objective To investigate the relationship between abnormally elevated parathyroid hormone level and nutritional status in uremia patients with parathyroid adenoma undergoing parathyroidectomy (PTX). Methods A total of 118 uremia patients with uremia hyperparathyroidism undergoing PTX treated in the Affiliated Hospital of Qingdao University during September 2015 to July 2020 were retrospectively analyzed. Their intact parathyroid hormone (iPTH), serum calcium, phosphate and alkaline phosphatase and the nutrition-related indexes of BMI and serum albumin one week before PTX and after PTX for 6 months were
collected and analyzed. Subjective global assessment (SGA) and Edmonton scoring for debilitating were used for the assessment of nutritional status. Results There were significant differences in serum iPTH (Z=-7.940, P＜0.001), calcium (Z=-9.101, P＜0.001), phosphate (Z=-8.396, P＜0.001), alkaline phosphatase (Z=-8.367, P＜0.001), albumin (Z=-7.940, P＜0.001) prealbumin (Z= -5.102, P＜0.001) and BMI (Z=-7.341, P＜0.001) before and after PTX. The changes of SGA score and Edmonton score indicated the improvement of nutrition and debilitating status after PTX. The preoperative iPTH level was negatively correlated with BMI (r=-0.272, P=0.003), serum albumin (r=-0.630, P＜0.001), prealbumin (r=-0.165, P=0.020) and SGA scores (r=-0.781, P＜0.001), and positively correlated with Edmonton score (r=0.611, P＜0.001). Conclusion The nutritional status was significantly different before and after PTX in uremia patients with hyperparathyroidism. Serum iPTH reduced, and nutrition indexes and debilitating status improved significantly after PTX.

Key words: Uremia, Hyperparathyroidism, Nutrition, Parathyroid hormone, Parathyroidectomy