Abstract: 【Abstract】Objective To observe the efficacy of hemodiafiltration with endogenous reinfusion (HFR) in maintenance hemodialysis (MHD) patients. Methods A total of 20 MHD patients were collected from Blood Purification Center, Zhongda Hospital Affiliated to Southeast University. After hemodialysis (HD) treatment for 4 weeks as the washout period, they were treated with the HD-HFR-HD mode as the three times of dialysis in a week for 4 weeks. Blood pressure, β2-microglobulin, C-reactive protein and inflammatory cytokines were examined before and after the HFR treatment. Dialysis adequacy and fatigue were observed in the HD and HFR treatment periods. Results Blood pressure was stable before and after HFR treatment. β2-microglobulin (t=1.557, P=0.040) decreased significantly. C-reactive protein (t=0.152, P=0.945), interleukin-2 (t=0.074, P=0.866), interleukin-6 (t=0.392, P=0.619), tumor necrosis factor-α (t=2.042, P=0.068) were also reduced but without statistical significance. After HFR, dialysis adequacy had no significant change (t=0.815, P=0.431), but fatigue score decreased significantly (t=3.834, P=0.001) as compared with those after HD. Conclusion Compared with HD, HFR significantly alleviates the microinflammatory status of the patients but without difference in dialysis adequacy.

Key words: Hemodiafiltration with endogenous reinfusion, Hemodialysis, Clinic application