Abstract: 【Abstract】Muscle atrophy is a common complication in the middle and late stage of chronic kidney disease (CKD), which mainly manifested as decreased muscle mass, decreased muscle strength, and decreased muscle function. The main cause of muscle atrophy is the enhancement of muscle protein degradation. The muscle protein degradation pathway can be stimulated by CKD pathological conditions such as the accumulation of toxic metabolites and the decrease of plasma pH value, then lead to muscle atrophy. This paper reviewed the research progress of muscle atrophy in CKD from the following five aspects: uremia toxin, metabolic acidosis, inflammation, hormones and intestinal flora.

Key words: Chronic kidney diseases, Muscular dystrophy, Signal pathway