Abstract: 【Abstract】Objective To use the Five- level EuroQol Five- dimensional Questionnaire (EQ- 5D- 5L) scale to measure the health utility value and to evaluate the quality of life and its related influencing factors in hemodialysis patients complicated with refractory secondary hyperparathyroidism (SHPT). Methods The ED-5Q-5L scale was used to evaluate the quality of life from multiple dimensions and to calculate the health utility values in a total of 150 hemodialysis patients with SHPT who received surgery and cinacalcet in China-Japan Friendship Hospital in Beijing. Multivariate regression analysis was used to analyze the related influencing factors. Results A total of 144 valid questionnaires were collected. The patients had an average age of 48.17± 10.95 years. The overall health utility value was 0.84±0.19, and the visual analogue scale (VAS) score was 80 (62.5, 90.0). Various degrees of pain or discomfort were present in 66.1% patients, and no difficulties in self-care were found in 86.3% patients. Regression analysis showed that treatment method, intact parathyroid hormone (iPTH) level and age impacted on the results. Patients in drug treatment group had higher health utility values (β=0.231, -0.176 and -0.188 respectively, P=0.039, 0.007 and 0.049 respectively). Conclusion The overall quality of life was improved in treated patients with refractory SHPT. However, pain, discomfort and psychological disorders are still problematic and should be taken into consideration. The data of converted utility value can be used to support the disease-related economic research.

Key words: EQ-5D-5L, Utility value, Refractory SHPT, Parathyroidectomy, Hemodialysis