Abstract: 【Abstract】objective To investigate the cardiac dysfunction characteristics and related factors in patients with sufficient hemodialysis. Methods Patients who have been treated with sufficient hemodialysis for more than 20 years in China-Japan Friendship Hospital were selected for this study. The general clinical data, laboratory and imaging results of these patients are collected for analysis. Results In the total of 20 patients, the dialysis vintage ranges from 20 to 34 years. About 75% of these patients' left ventricular systolic function remains within the normal range; about 35% of them have suffered different degrees of left ventricular systolic dysfunction (LVDD); and about 70% of them have suffered valve degenerative changes and regurgitation.
More than 35% of them have also suffered left atrial enlargement, left ventricular hypertrophy, abnormal ventricular wall movement, pericardial effusion and other cardiac damages. Biochemical results showed that the serum cardiac injury markers such as high-sensitivity troponin T(HS cTnT), high-sensitivity troponin I (HS cTnI), B-type natriuretic peptide(BNP)and N-terminal natriuretic peptide precursor (NT Pro BNP) increased significantly in about 50% of the patients. Spearman correlation analysis shows that age is positively related to LVDD(β=0.583，P=0.07), but there is no specific correlation between heart disease and dialysis vintage, the usage of low- molecular weight heparin, ACEI /ARB drugs, whether combined hemodialysis with filtration and hemoperfusion therapy. Conclusions With the increase of age and dialysis vintage, although the left ventricular systolic function could be maintained at a normal level in most patients, they still suffer from extensive cardiac structure damage and decreased left ventricular diastolic function.

Key words: Hemodialysis, Cardiac function, Dialysis age