Abstract: 【Abstract】Objective Blood pressure variation is closely related to cardiovascular and cerebrovascular events. Nevertheless, the relationship between the variation of blood pressure measured at clinic and the residual renal function and prognosis of the peritoneal dialysis (PD) patients was rarely studied. Methods A total of 515 PD patients were enrolled in this study. They were followed up regularly, and their clinical indicators and laboratory test results during the follow-up period were collected. According to the interquartile mean arterial pressure variation values (3.85, 9.43, 12.4, 16.4, and 48.8), the enrolled patients were divided into four groups: low variation group (3.85～9.43), low average variation group (9.43～12.4), high average variation group (12.4～16.4), and high variation group (16.4～48.8); patient with a boundary value was arranged into the next group. Clinical and laboratory data were compared among the four groups. Results There were significant differences among low variation group, low average variation group, high average variation group and high variation group in serum albumin (37.6±4.5g/l, 37.0±5.4g/l, 36.8± 5.3g/l and 34.8±5.2g/l respectively; F=5.385, P＜0.001), initial urine volume [699.0 (504.0, 1000.0)ml, 671.0 (407.0, 946.0)ml, 611.0 (493.5, 784.0)ml and 494.0 (296.0, 794.5)ml respectively; H=16.222, P=0.001], average urine volume in the followup period [706.8 (501.0, 913.9)ml, 657.7 (510.7, 844.4)ml, 559.2 (430.8, 754.4)ml and 487.6 (333.4, 748.9)ml respectively; H=25.209, P＜0.001], peritoneal Kt/V [1.10 (0.90, 1.50), 1.14 (0.81, 1.48), 1.18 (0.92, 1.59) and 1.32 (0.98, 1.69) respectively; H=13.147, P=0.004], and residual kidney Kt/V [0.90 (0.40, 1.30), 0.75 (0.50, 1.08), 0.69 (0.30, 1.16) and 0.56 (0.25, 0.88) respectively; H=21.384, P＜0.001]. Spearman's correlation analysis showed a negative correlation between blood pressure variation and average urine volume (β=-0.230, P＜0.001). Conclusion In PD patients, serum albumin and residual urine volume were closely related to the clinic blood pressure variation. PD patients with low blood pressure variation usually had higher residual urine volume and better nutritional status and will directly relate to their long-term prognosis.

Key words: Peritoneal dialysis, Clinic blood pressure, Residual renal function, Residual urine volume, Nutritional status