Abstract: 【Abstract】Objective To investigate the relationship between bone mineral density and cardiac valve calcification (CVC) in maintenance hemodialysis (MHD) patients. Method A total of 97 MHD patients admitted to The Second Hospital of Anhui Medical University were enrolled in this study. They were divided into combined CVC group and non-combined CVC group based on the manifestations in echocardiograph. Bone mineral density was compared between the two groups. Binary Logistic regression was conducted to explore the factors for combined CVC. Results Thirty patients had combined CVC in mitral and aortic valves with the
prevalence of combined CVC of 30.93%. Bone mineral density was lower in combined CVC group than in non-combined CVC group (t= -3.650, P=0.001). Older age, longer duration and higher neutrophil-lymphocyte ratio (NLR) were present in combined CVC group as compared with those in non-combined CVC group. Serum phosphate and intact parathyroid hormone (iPTH) were higher in combined CVC group than in non-combined CVC group (t=3.580 and 2.465, P=0.001 and 0.016). Binary Logistic regression found that hyperphosphatemia (OR=16.301, P=0.001), higher iPTH (OR=1.002, P=0.004), higher NLR (OR=1.561,P=0.042), and
lower bone density (OR=0.003, P=0.010) correlated with the combined CVC in MHD patients. Conclusion Hyperphosphatemia, higher iPTH, higher NLR and lower bone density were the risk factors for combined CVC in MHD patients.

Key words: Maintenance hemodialysis, Cardiac valve calcification, Bone mineral density, Neutrophillymphocyte ratio