Abstract: 【Abstract】The clearance capacity of uremic toxin is severely impaired in patients with chronic kidney disease (CKD) than that in normal people. With the accumulation of uremic toxins, many systems including the cardiovascular system are damaged in CKD patients. Blood purification can remove most uremic toxins through diffusion, convection and adsorption. However, the removal rates for protein binding toxins are limited, which affects the prognosis of CKD patients. In this paper, we reviewed the progress of protein binding toxins and cardiovascular disease in CKD patients, and the clearance of protein binding toxins by blood purification.
In this paper, we reviewed the relationship between protein binding toxins and the progress of cardiovascular disease in CKD patients, and the effect of blood purification methods on the removal of protein bining toxins.

Key words: Chronic kidney disease, Blood purification, Cardiovascular disease, Protein binding toxins