Abstract: 【Abstract】With the Innovation of continuous renal replacement therapies (CRRT) technology and dialysis membrane, the treatment methods for sepsis complicated with acute kidney injury have been gradually diversified in recent years. Among those innovation, High cut-off (HCO) membrane have more promising benefits in the removal of inflammatory factors which could not be effectively removed by the traditional high-flux filters. HCO membrane is expected to be more selective in the clinical practice to remove large molecular weight inflammatory mediators, thus providing effective intervention for systemic inflammation status by
blood purification in addition to anti-infection therapy. Our review focuses specifically on the clinical application of HCO therapy, including published studies focused on the removal of inflammatory cytokines by HCO membrane and its improvement in prognosis. We also summarize the differences of those published studies and potential applications of HCO membrane.

Key words: Septic acute kidney injury, High cut-off membranes, Continuous renal replacement therapy, Cytokine