Abstract: 【Abstract】Objective To systematically review the prevalence of frailty in chronic kidney disease (CKD) patients. Methods The Cochrane Library, PubMed, Embase, Web of Science and CNKI, VIP, Wan-Fang, CBM databases were searched to collect studies on prevalence of frailty in CKD patients from inception to March 30, 2021. Meta-analysis was performed by using Stata 16.0. Result A total of 30 studies which included 9,496 participants were analyzed. Meta-analysis showed that the prevalence of frailty in CKD patients was 32.5% (ES=0.325, 95% CI: 0.261~0.390, P<0.001), and the prevalence of pre- frailty was 39.6% (ES=0.396, 95% CI: 0.348~0.444, P<0.001). Conclusion The prevalence of frailty and pre-frailty was higher in CKD patients. The prevalence of frailty was related to geographic regions, gender, treatment methods and assessment tools. Therefore, medical staff should pay more attention to identify frailty in CKD patients, and formulate specific intervention plans for them to delay the occurrence and progress of frailty.

Key words: Chronic kidney disease, Frailty, Pre-frailty, Prevalence, Meta-analysis