Abstract: Objective To analyze the characteristics of thyroid function and the relationship with cardiac
structure and function in maintenance hemodialysis (MHD) patients. Methods A total of 83 patients on regular hemodialysis for more than 3 months at The Affiliated Hospital of Xuzhou Medical University during the
period from January 2019 to December 2020 were enrolled in this study. Thyroid function characteristics of
the patients and the relationship with heart structure and function were analyzed. Results Thyroid dysfunction was found in 30 (36.1%) cases, of which most had a decrease of FT3 (10.8%) and an increase of TSH
(13.3% ). Compared with the thyroid normal group, HDL (t=2.594 P=0.011) was lower, and serum LDL
(t=2.520 P=0.015), triglycerides (Z=2.796, P=0.005) and C-reactive protein (CRP) (Z=2.067, P=0.009) were
higher in the thyroid dysfunction group; in addition, the left atrium diameter (t=2.373, P=0.020), left ventricular diastolic end diameter (t=2.390 P=0.021), left ventricular posterior diastolic wall thickness (t=2.561,
P=0.014), interventricular septal thickness (t=2.688, P=0.010) and left ventricular mass index (t=3.785,
P＜0.001) were higher, and the left ventricular ejection fraction (t=3.721, P＜0.001) was lower in the thyroid
dysfunction group. Patients with left ventricular hypertrophy had older age (t=2.159, P=0.034), longer dialysis
age (Z=2.769, P=0.006), higher levels of CRP (Z=4.196, P＜0.001), LDL (t=3.059, P=0.003), parathyroid hormone (PTH) (Z=2.139, P=0.032) and TSH (Z=2.827, P=0.005), but lower levels of hemoglobin (t=2.616,
P=0.011), pre- albumin (t=2.515, P=0.014), albumin (t=2.643, P=0.010), FT3 (t=4.581, P＜0.001) and FT4
(t=3.693, P＜0.001), as compared with those in the patients without left ventricular hypertrophy. Binary logistic analysis showed that hemoglobin (B=0.034, OR=0.967, 95% CI 0.939～0.995, P=0.022), FT3 (B=1.195,
OR=0.303, 95% CI 0.128～0.713, P=0.006) and FT4 (B=0.427, OR=0.653, 95% CI 0.487～0.875, P=0.004)
were the protective factor for patients to have normal left ventricular thickness. Conclusion Lower FT3 and
higher TSH are common in MHD patients, and are the risk factors for left ventricular hypertrophy in MHD patients.

Key words: Thyroid function; , Heart structure; , Maintenance hemodialysis